Journal article
Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro
C Zhang, DV Baimoukhametova, CM Smith, JS Bains, AL Gundlach
Psychopharmacology | SPRINGER | Published : 2017
Abstract
Relaxin-3/RXFP3 signalling is proposed to be involved in the neuromodulatory control of arousal- and stress-related neural circuits. Furthermore, previous studies in rats have led to the proposal that relaxin-3/RXFP3 signalling is associated with activation of the hypothalamic-pituitary-adrenal axis, but direct evidence for RXFP3-related actions on the activity of hypothalamic corticotropin-releasing hormone (CRH) neurons is lacking. In this study, we investigated characteristics of the relaxin-3/RXFP3 system in mouse hypothalamus. Administration of an RXFP3 agonist (RXFP3-A2) intra-cerebroventricularly or directly into the paraventricular nucleus of hypothalamus (PVN) of C57BL/6J mice did n..
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Awarded by State Government of Victoria
Funding Acknowledgements
This research was supported by a National Health and Medical Research Council of Australia Research Fellowship and Project Grant (1106330, 1024885, ALG), a Brain & Behavior Research Foundation (USA) NARSAD Independent Investigator Award (ALG); by the Canadian Institutes of Health Research and Brain Canada (JSB); and by the Victorian Government Operational Infrastructure Support Programme. CZ was the recipient of a Bethlehem Griffiths Research Foundation Postgraduate Scholarship and a Rebecca Hotchkiss International Scholar Exchange Travelling Fellowship.